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The Research Network on Law and Neuroscience, supported by the John D. and Catherine T. MacArthur Foundation, addresses a focused set of closely-related problems at the intersection of neuroscience and criminal justice: 1) determining the law-relevant mental states of defendants and witnesses; 2) assessing a defendant’s capacity for self-regulating his behavior; and 3) assessing whether, and if so how, neuroscientific evidence should be admitted and evaluated in individual cases.